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Home - Products - GPCR/G Protein - Chemokine Receptor - GW-766994 R-form

GW-766994 R-form

CAS No. 408303-44-6

GW-766994 R-form( —— )

Catalog No. M14405 CAS No. 408303-44-6

GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GW-766994 R-form
  • Note
    Research use only, not for human use.
  • Brief Description
    GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
  • Description
    GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    408303-44-6
  • Formula Weight
    451.348
  • Molecular Formula
    C21H24Cl2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (R)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.
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